Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (22), p.4007-4010
2003
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck)
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (22), p.4007-4010
- Ort / Verlag
- England
- Erscheinungsjahr
- 2003
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A novel series of 2-amino-5-carboxamidothiazoles were identified as inhibitors of Lck. Structure-activity studies demonstrate the structural requirements for potent Lck activity. Cyclopropylamide 11d is a potent Lck inhibitor having sub-micromolar activity in a PBL proliferation assay.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XDOI: 10.1016/j.bmcl.2003.08.054Titel-ID: cdi_proquest_miscellaneous_71332841
- Format
- –
- Schlagworte
- Amino Acid Sequence, Binding Sites, Drug Design, Enzyme Inhibitors - chemical synthesis, Enzyme Inhibitors - pharmacology, Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - antagonists & inhibitors, Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - chemistry, Models, Molecular, Molecular Structure, Structure-Activity Relationship, Thiazoles - chemical synthesis, Thiazoles - pharmacology