Details

Autor(en) / Beteiligte

• Beltran, William A.
• Chahory, Sabine
• Gnirs, Kirsten
• Escriou, Catherine
• Blot, Stéphane
• Clerc, Bernard

Titel

The electroretinographic phenotype of dogs with Golden Retriever muscular dystrophy

Ist Teil von

• Veterinary ophthalmology, 2001-12, Vol.4 (4), p.277-282

Ort / Verlag

Oxford, UK: Blackwell Science Ltd

Erscheinungsjahr

2001

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective  To characterize the flash electroretinogram (ERG) in the Golden Retriever muscular dystrophy (GRMD) dog and to compare the results with those from a control group of Golden Retrievers. To investigate whether similar abnormalities of the ERG as those found in a majority of human patients with Duchenne muscular dystrophy (DMD) are also observed in the GRMD dog, the canine model for DMD. Animals  Five GRMD dogs and five age‐matched clinically normal Golden Retrievers. Procedure  An ophthalmic examination was carried out prior to performing electroretinography under general anesthesia. Rod, combined rod–cone and oscillatory potentials responses were recorded after dark adaptation. Responses to 30‐Hz‐flicker were recorded after light adaptation. The ERG responses of the GRMD dogs were compared with those of the control dogs by use of a Wilcoxon signed rank test. Results  GRMD dogs had significantly reduced a and b‐wave amplitudes after dim white flash stimuli (rod response) and reduced a‐wave amplitude after bright white flash stimuli (rod–cone response). Conclusion and clinical relevance  The ERG abnormalities observed in the GRMD dog suggest a dysfunction in the rod signaling pathway. These ERG alterations are different from those observed in human patients with DMD.