Details

Autor(en) / Beteiligte

• Sminia, K. Axel Hartmann, Christoph J. Schneider, Ulrich M. Carl, Adrianus J. van der Kleij, Ben J. Slotman, Maarten C. C. M. Hulshof, Peter

Titel

Radiosensitizing Effect of Carbogen Breathing during Pulsed Irradiation of the Rat R1H Tumor

Ist Teil von

• Acta oncologica, 2001, Vol.40 (7), p.870-874

Ort / Verlag

Basingstoke: Informa UK Ltd

Erscheinungsjahr

2001

Quelle

Taylor & Francis Journals Auto-Holdings Collection

Beschreibungen/Notizen

• The objective of the present study was to investigate the radiosensitizing effect of carbogen breathing during pulsed x-ray irradiation in an experimental tumor model. Rat R1H rhabdomyosarcoma tumors were irradiated with 36 Gy total dose in 1 Gy high dose rate pulses, either hourly repeated, or in an 'office hours' protocol with irradiation-free overnight intervals. With the hourly, pulsed irradiation scheme, tumor growth delay (TGD) was significantly increased from 24.4 &#45 0.7 days in air-breathing animals to 29.0 &#45 0.9 days in animals breathing carbogen during irradiation. With irradiation during office hours, the TGD was shortened, and carbogen was less effective. The data show that carbogen acts as a radiosensitizer when applied during pulsed irradiation. Translation of the experimental data to clinical practice indicates that hyperoxygenation of the tumor during pulsed dose rate (PDR) or high dose rate (HDR) brachytherapy might enhance the tumor response of patients.