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The Journal of thoracic and cardiovascular surgery, 2000-08, Vol.120 (2), p.342-349
2000
Details
- Autor(en) / Beteiligte
- Titel
- Early effects of right ventricular volume overload on ventricular performance and β-adrenergic signaling
- Ist Teil von
- The Journal of thoracic and cardiovascular surgery, 2000-08, Vol.120 (2), p.342-349
- Ort / Verlag
- Philadelphia, PA: Elsevier Inc
- Erscheinungsjahr
- 2000
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Objective: Right ventricular dysfunction is a poorly understood but persistent clinical problem. This study was undertaken to evaluate ventricular performance and β-adrenergic receptor signaling in a tricuspid regurgitation model of right ventricular overload. Methods: Seventeen dogs were chronically instrumented with epicardial dimension transducers. By means of the shell-subtraction model, right ventricular pressure-volume relationships were evaluated in normal and right ventricular overload states. Right ventricular chamber performance was quantified by the stroke work at an end-diastolic volume relationship. Results: Right ventricular volume overload caused a 28% ± 11% and 31% ± 9% decline in chamber performance acutely and at 1 week, respectively, whereas end-diastolic volume increased from 45 ± 21 to 60 ± 30 mL (P =.019). β-Adrenergic receptor signaling in myocardial samples was assessed, examining adenylyl cyclase and G-protein–coupled receptor kinase activity. Stimulated adenylyl cyclase activity significantly decreased, and G-protein–coupled receptor kinase activity significantly increased in both left and right ventricular samples caused by increased levels of β-adrenergic receptor kinase 1. No change in β-adrenergic receptor density was seen at 1 week. Conclusions: Early right ventricular overload is associated with impaired right ventricular chamber contractility, dilation, and, importantly, a biventricular alteration of β-adrenergic receptor signaling. (J Thorac Cardiovasc Surg 2000;119:342-9)
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-5223eISSN: 1097-685XDOI: 10.1067/mtc.2000.107278Titel-ID: cdi_proquest_miscellaneous_71274631
- Format
- –
- Schlagworte
- Adenylyl Cyclases - metabolism, Analysis of Variance, Animals, Biological and medical sciences, Cardiology. Vascular system, Dogs, Endocardial and cardiac valvular diseases, GTP-Binding Proteins - metabolism, Heart, Hemodynamics, Linear Models, Medical sciences, Myocardium - metabolism, Neuropeptide Y - metabolism, Receptors, Adrenergic, beta - physiology, Signal Transduction, Stroke Volume, Tricuspid Valve Insufficiency - physiopathology, Ventricular Dysfunction, Right - physiopathology, Ventricular Pressure