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HBV DNA integration and HBV-transcript expression in non-B, non-C hepatocellular carcinoma in Japan
Journal of medical virology, 2003-12, Vol.71 (4), p.492-498
Tamori, Akihiro
Nishiguchi, Shuhei
Kubo, Shoji
Narimatsu, Takashi
Habu, Daiki
Takeda, Tadashi
Hirohashi, Kazuhiro
Shiomi, Susumu
2003
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Tamori, Akihiro
Nishiguchi, Shuhei
Kubo, Shoji
Narimatsu, Takashi
Habu, Daiki
Takeda, Tadashi
Hirohashi, Kazuhiro
Shiomi, Susumu
Titel
HBV DNA integration and HBV-transcript expression in non-B, non-C hepatocellular carcinoma in Japan
Ist Teil von
Journal of medical virology, 2003-12, Vol.71 (4), p.492-498
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2003
Quelle
MEDLINE
Beschreibungen/Notizen
Few studies have examined the etiology of hepatocellular carcinoma (HCC) in patients without hepatitis virus infection. We evaluated the role of occult hepatitis B virus (HBV) infection in the development of HCC in Japanese patients without hepatitis B surface antigen (HBsAg) and antibodies to hepatitis C antigen (anti‐HCV). Twenty‐one HBsAg negative and anti‐HCV negative (non‐B, non‐C) patients with HCC were studied. HBV DNA in serum and HBV transcripts in liver were examined by polymerase chain reaction (PCR) or reverse transcription and PCR. HBV DNA integration was examined by Southern blot analysis or cassette‐ligation‐mediated PCR as described previously. p53 mutations were examined by direct sequencing. HBV DNA was not detected in serum from any patients. HBV‐related transcripts were detected in 5 of 7 HCCs from patients with antibodies to hepatitis core antigen (anti‐HBc) and in 3 of 14 HCCs from patients without anti‐HBc (P = 0.0261). HBV DNA was integrated into human genome in two non‐B, non‐C HCCs. Of the 14 patients without anti‐HBc, 5 had a history of excessive alcohol intake. In exons 5 through 8 of the p53 gene, mutations were detected in 2 of 8 HCCs with HBV‐transcripts and in 5 of 13 HCCs without such transcripts. p53 mutation at codon 159 was found in 2 of 6 patients with excessive alcohol intake without HBV‐transcripts. These results suggested that occult HBV infection might play an important role in hepatocarcinogenesis in non‐B, non‐C patients with anti‐HBc and that excessive alcohol intake might be related to HCC in non‐B, non‐C patients in Japan. J. Med. Virol. 71:492–498, 2003. © 2003 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0146-6615
eISSN: 1096-9071
DOI: 10.1002/jmv.10514
Titel-ID: cdi_proquest_miscellaneous_71257156
Format
–
Schlagworte
Adult
,
Aged
,
Base Sequence
,
Biological and medical sciences
,
Carcinoma, Hepatocellular - etiology
,
Carcinoma, Hepatocellular - virology
,
DNA, Viral - genetics
,
DNA, Viral - isolation & purification
,
Female
,
Fundamental and applied biological sciences. Psychology
,
Genes, p53
,
Hepatitis B - complications
,
Hepatitis B - virology
,
Hepatitis B Antibodies - blood
,
Hepatitis B Surface Antigens - blood
,
Hepatitis B virus - genetics
,
Hepatitis B virus - isolation & purification
,
Hepatitis B virus - pathogenicity
,
Hepatitis C Antibodies - blood
,
hepatocarcinogenesis
,
Human viral diseases
,
Humans
,
Infectious diseases
,
Japan
,
Liver Neoplasms - etiology
,
Liver Neoplasms - virology
,
Male
,
Medical sciences
,
Microbiology
,
Middle Aged
,
Miscellaneous
,
Molecular Sequence Data
,
Mutation
,
occult HBV infection
,
p53 mutation
,
RNA, Messenger - genetics
,
RNA, Messenger - metabolism
,
RNA, Viral - genetics
,
RNA, Viral - metabolism
,
Transcription, Genetic
,
Tumors
,
Viral diseases
,
Virology
,
Virus Integration - genetics
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