Details

Autor(en) / Beteiligte

• White, Harvey D
• Simes, R. John
• Anderson, Neil E
• Hankey, Graeme J
• Watson, John D.G
• Hunt, David
• Colquhoun, David M
• Glasziou, Paul
• MacMahon, Stephen
• Kirby, Adrienne C
• West, Malcolm J
• Tonkin, Andrew M

Titel

Pravastatin Therapy and the Risk of Stroke

Ist Teil von

• The New England journal of medicine, 2000-08, Vol.343 (5), p.317-326

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

2000

Quelle

MEDLINE

Beschreibungen/Notizen

• Cerebrovascular disease is the second leading cause of death worldwide 1 , 2 and the leading cause of long-term disability in developed countries. 3 , 4 There has been controversy about whether there is an association between cholesterol levels and the risk of stroke; a meta-analysis found no clear evidence of such an association. 5 Most of the studies made no distinction between ischemic and hemorrhagic strokes, which have different pathophysiologic mechanisms. A positive association between increasing cholesterol levels and ischemic stroke due to atherothrombosis in a large artery may be offset by a possible association between low cholesterol levels and hemorrhagic stroke. Studies of . . .