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Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content
Ist Teil von
Journal of applied physiology (1985), 2000-07, Vol.89 (1), p.104-110
Ort / Verlag
Bethesda, MD: Am Physiological Soc
Erscheinungsjahr
2000
Quelle
MEDLINE
Beschreibungen/Notizen
Departments of 1 Medicine and 2 Radiology, University
of Pittsburgh, Pittsburgh, Pennsylvania 15261; and 3 School
of Physical and Health Education, Queen's University, Kingston,
Ontario, Canada K7L 3N6
The purpose of
this investigation was to validate that in vivo measurement of skeletal
muscle attenuation (MA) with computed tomography (CT) is associated
with muscle lipid content. Single-slice CT scans performed on phantoms
of varying lipid concentrations revealed good concordance between
attenuation and lipid concentration ( r 2 = 0.995); increasing the phantom's lipid concentration by 1 g/100 ml
decreased its attenuation by ~1 Hounsfield unit (HU). The test-retest coefficient of variation for two CT scans performed in six volunteers was 0.51% for the midthigh and 0.85% for the midcalf, indicating that
the methodological variability is low. Lean subjects had significantly
higher ( P < 0.01) MA values (49.2 ± 2.8 HU) than did obese nondiabetic (39.3 ± 7.5 HU) and obese Type 2 diabetic (33.9 ± 4.1 HU) subjects, whereas obese Type 2 diabetic subjects had lower MA values that were not different from obese nondiabetic subjects. There was also good concordance between MA in midthigh and midcalf ( r = 0.60, P < 0.01),
psoas ( r = 0.65, P < 0.01), and
erector spinae ( r = 0.77, P < 0.01) in
subsets of volunteers. In 45 men and women who ranged from lean to
obese (body mass index = 18.5 to 35.9 kg/m 2 ),
including 10 patients with Type 2 diabetes mellitus, reduced MA was
associated with increased muscle fiber lipid content determined with
histological oil red O staining ( P = 0.43,
P < 0.01). In a subset of these volunteers
( n = 19), triglyceride content in percutaneous biopsy
specimens from vastus lateralis was also associated with MA
( r = 0.58, P = 0.019). We conclude
that the attenuation of skeletal muscle in vivo determined by CT is
related to its lipid content and that this noninvasive method may
provide additional information regarding the association between muscle
composition and muscle function.
triglyceride; body composition; obesity; Type 2 diabetes mellitus