Annals of the New York Academy of Sciences, 2000-05, Vol.902 (1), p.272-282
2000
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- The Fat Mouse: A Powerful Genetic Model to Study Hemostatic Gene Expression in Obesity/NIDDM
- Ist Teil von
- Annals of the New York Academy of Sciences, 2000-05, Vol.902 (1), p.272-282
- Ort / Verlag
- Oxford, UK: Blackwell Publishing Ltd
- Erscheinungsjahr
- 2000
- Quelle
- Access via Wiley Online Library
- Beschreibungen/Notizen
- : In this chapter, we summarize our studies on plasminogen activator inhibitor 1 (PAI‐1), tissue factor, and transforming growth factor beta (TGF‐β) expression in obesity, using genetically obese mice as a model. These studies emphasize the key role played by the adipocyte, a cell whose numbers, size, and metabolic activity are grossly altered in obesity/NIDDM. They also implicate multiple cytokines, hormones, and growth factors in the abnormal expression of these and perhaps other hemostatic genes by adipocytes in obesity/NIDDM. These studies demonstrate that tumor necrosis factor alpha (TNF‐α) plays a central role in the expression of hemostatic genes in this disorder.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0077-8923eISSN: 1749-6632DOI: 10.1111/j.1749-6632.2000.tb06322.xTitel-ID: cdi_proquest_miscellaneous_71203094
- Format
- –
- Schlagworte
- Adipocytes - physiology, Animals, Diabetes Mellitus - genetics, Diabetes Mellitus, Type 2 - genetics, Gene Expression Regulation, Hemostasis - genetics, Humans, Mice, Mice, Obese - genetics, Obesity - genetics, Plasminogen Activator Inhibitor 1 - genetics, Transforming Growth Factor beta - genetics, Tumor Necrosis Factor-alpha - physiology