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Optical properties of native and coagulated porcine liver tissue between 400 and 2400 nm
Lasers in surgery and medicine, 2001-09, Vol.29 (3), p.205-212
Ritz, Joerg-P.
Roggan, Andre
Isbert, Christoph
Müller, Gerhard
Buhr, Heinz J.
Germer, Christoph-T.
2001
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Ritz, Joerg-P.
Roggan, Andre
Isbert, Christoph
Müller, Gerhard
Buhr, Heinz J.
Germer, Christoph-T.
Titel
Optical properties of native and coagulated porcine liver tissue between 400 and 2400 nm
Ist Teil von
Lasers in surgery and medicine, 2001-09, Vol.29 (3), p.205-212
Ort / Verlag
New York: John Wiley & Sons, Inc
Erscheinungsjahr
2001
Quelle
MEDLINE
Beschreibungen/Notizen
Background and Objective Laser induced thermotherapy (LITT) is a promising treatment for irresectable liver tumors. For predicting the effects of laser applications and optimizing irradiation planning in LITT, knowledge about light distribution in tissue, optical tissue properties (absorption, scattering, anisotropy, penetration depth) and their changes due to thermal denaturation is indispensable. Study Design/Materials and Methods The optical parameters in healthy porcine liver were determined in the native state and after thermal coagulation using a double integrating sphere system in the wavelength range of 400–2400 nm. Results Optical parameters showed significant fluctuations in the examined wavelength range mainly due to the water and hemoglobin content in the tissue. The greatest optical penetration depth of 7.46 mm was achieved at 1070 nm. After thermal coagulation, a clear increase in scattering and a slight decrease in absorption was found, which results in a decreased optical penetration depth. Conclusions In order to ensure a safe and effective procedure, an adjustment of the laser power to the decreasing penetration depth is recommended during therapy. These results provide a better understanding of laser‐tissue interaction and may be helpful to investigators in the field of light dosimetry in liver tissue. Lasers Surg. Med. 29:205–212, 2001. © 2001 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0196-8092
eISSN: 1096-9101
DOI: 10.1002/lsm.1134
Titel-ID: cdi_proquest_miscellaneous_71201811
Format
–
Schlagworte
Animals
,
Anisotropy
,
Biological and medical sciences
,
dosimetry
,
heat-induced changes
,
Hyperthermia, Induced
,
Induced hyperthermia. Cryotherapy
,
Laser Coagulation
,
laser-induced thermotherapy
,
Light
,
Liver - physiology
,
Liver - radiation effects
,
liver metastases
,
Liver Neoplasms - surgery
,
Medical sciences
,
Monte Carlo Method
,
optical properties
,
Optics and Photonics
,
Scattering, Radiation
,
Swine
,
Treatment with physical agents
,
Treatment. General aspects
,
Tumors
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