Details

Autor(en) / Beteiligte

• Pham, Daphne Q.‐D.
• Brown, Susan E.
• Knudson, Dennis L.
• Winzerling, Joy J.
• Dodson, Mark S.
• Shaffer, James J.

Titel

Structure and location of a ferritin gene of the yellow fever mosquito Aedes aegypti

Ist Teil von

• European journal of biochemistry, 2000-06, Vol.267 (12), p.3885-3890

Ort / Verlag

Oxford, UK: Blackwell Science Ltd

Erscheinungsjahr

2000

Quelle

MEDLINE

Beschreibungen/Notizen

• We have isolated and sequenced a genomic clone encoding the 24‐ and 26‐kDa ferritin subunits in the mosquito Aedes aegypti (Rockefeller strain). The A. aegypti gene differs from other known ferritin genes in that it possesses an additional intron and an unusually large second intron. The additional intron is located within the 5′ untranslated region, between the CAP site and the start codon. The second intron contains numerous putative transposable elements. In addition, unlike the human and rat ferritin genes, the A. aegypti ferritin gene is a single copy gene, located at 88.3% FLpter on the q‐arm of chromosome 1. Primer extension analysis indicates that the A. aegypti ferritin gene has multiple transcriptional start sites. A differential usage of these sites is observed with varied cellular iron concentrations.