Details

Autor(en) / Beteiligte

• ITOH, Hiroki
• NAGANO, Toshiaki
• TAKEYAMA, Masaharu

Titel

Effects of Mosapride Citrate on Human Plasma Levels of Motilin, Gastrin, Somatostatin, and Secretin

Ist Teil von

• Biological and Pharmaceutical Bulletin, 2001, Vol.24(9), pp.1072-1075

Ort / Verlag

Tokyo: The Pharmaceutical Society of Japan

Erscheinungsjahr

2001

Quelle

MEDLINE

Beschreibungen/Notizen

• The effect of mosapride citrate (mosapride) on plasma levels of gastrointestinal peptides (motilin, gastrin, somatostatin, and secretin) was studied in five healthy volunteers. After a single oral administration of mosapride (15 mg), the plasma mosapride level (85.0±13.7 ng/ml) was highest in the 60-min sample after the administration and then the plasma level fell. Peak plasma motilin levels (18.6±1.7 pg/ml) were achieved 60 min after administration of mosapride (p<0.01 vs. placebo), and returned to baseline levels within a further 120 min. Plasma gastrin levels (42.4±3.6 pg/ml) increased 60 min after administration of mosapride (p<0.01 vs. placebo). Plasma somatostatin and secretin levels did not change significantly. These results suggest that the pharmacological effects of mosapride on gastrointestinal functions are closely related to changes in motilin-immunoreactive substance levels in human plasma.