Details

Autor(en) / Beteiligte

• RODRIGUEZ, Jose
• MUNSELL, Mark
• ROMAGUERA, Jorge
• CABANILLAS, Fernando F
• CHAMPLIN, Richard E
• KHOURI, Issa F
• YAZJI, Salim
• HAGEMEISTER, Fredrick B
• YOUNES, Anas
• ANDERSSON, Borje
• GIRALT, Sergio
• GAJEWSKI, James
• DE LIMA, Marcos
• COURIEL, Daniel

Titel

Impact of High-Dose Chemotherapy on Peripheral T-Cell Lymphomas

Ist Teil von

• Journal of clinical oncology, 2001-09, Vol.19 (17), p.3766-3770

Ort / Verlag

Baltimore, MD: American Society of Clinical Oncology

Erscheinungsjahr

2001

Quelle

MEDLINE

Beschreibungen/Notizen

• To evaluate the outcome of high-dose chemotherapy (HDCT) and autologous or allogeneic hematopoietic transplantation in patients with peripheral T-cell lymphoma (PTCL) who experienced disease recurrence after prior conventional chemotherapy. We performed a retrospective analysis of 36 PTCL patients from the University of Texas M.D. Anderson Cancer Center treated between 1989 and 1998 with HDCT and autologous or allogeneic hematopoietic transplantation. A total of 36 patients were studied (29 received autologous transplantation, and seven received allogeneic transplantation). The overall survival rate at 3 years was 36% (95% confidence interval [CI], 23% to 59%), and the progression-free survival (PFS) rate was 28% (95% CI, 16% to 49%). The pretransplant serum lactate dehydrogenase level was the most important prognostic factor for both survival and PFS rates (P < .001). A Pretransplant International Prognostic Index score of < or = 1 indicated a superior survival rate (P = .036) but not an improved PFS rate. A median follow-up of 43 months (range, 13 to 126 months) showed 13 patients (36%) were still alive with no evidence of disease. Our results are comparable to the published data on HDCT in B-cell non-Hodgkin's lymphoma (NHL) patients despite the fact that patients with PTCL are known to have a worse outcome compared with B-cell NHL patients. Considering the dismal outcome of conventional chemotherapy in PTCL patients, these data suggest the hypothesis that the poor prognostic implication of T-cell phenotyping in NHL might be overcome by frontline HDCT and transplantation.