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Immunoglobulin framework-derived peptides function as cytotoxic T-cell epitopes commonly expressed in B-cell malignancies
Ist Teil von
Nature medicine, 2000-06, Vol.6 (6), p.667-672
Ort / Verlag
United States: Nature Publishing Group
Erscheinungsjahr
2000
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Although the idiotypic structures of immunoglobulin from malignant B cells
were the first tumor-specific determinants recognized, and clinical vaccination
trials have demonstrated induction of tumor-specific immunity, the function
of immunoglobulin-specific CD8+ cytotoxic T lymphocytes in
tumor rejection remains elusive. Here, we combined bioinformatics and a T
cell-expansion system to identify human immunoglobulin-derived peptides capable
of inducing cytotoxic T-lymphocyte responses. Immunogenic peptides were derived
from framework regions of the variable regions of the immunoglobulin that
were shared among patients. Human-leukocyte-antigen-matched and autologous
cytotoxic T lymphocytes specific for these peptides killed primary malignant
B cells, demonstrating that malignant B cells are capable of processing and
presenting such peptides. Targeting shared peptides to induce T-cell responses
might further improve current vaccination strategies in B-cell malignancies.