Details

Autor(en) / Beteiligte

• Gribben, John G
• Trojan, Andreas
• Schultze, Joachim L
• Witzens, Mathias
• Vonderheide, Robert H
• Ladetto, Marco
• Donovan, John W

Titel

Immunoglobulin framework-derived peptides function as cytotoxic T-cell epitopes commonly expressed in B-cell malignancies

Ist Teil von

• Nature medicine, 2000-06, Vol.6 (6), p.667-672

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2000

Quelle

MEDLINE

Beschreibungen/Notizen

• Although the idiotypic structures of immunoglobulin from malignant B cells were the first tumor-specific determinants recognized, and clinical vaccination trials have demonstrated induction of tumor-specific immunity, the function of immunoglobulin-specific CD8+ cytotoxic T lymphocytes in tumor rejection remains elusive. Here, we combined bioinformatics and a T cell-expansion system to identify human immunoglobulin-derived peptides capable of inducing cytotoxic T-lymphocyte responses. Immunogenic peptides were derived from framework regions of the variable regions of the immunoglobulin that were shared among patients. Human-leukocyte-antigen-matched and autologous cytotoxic T lymphocytes specific for these peptides killed primary malignant B cells, demonstrating that malignant B cells are capable of processing and presenting such peptides. Targeting shared peptides to induce T-cell responses might further improve current vaccination strategies in B-cell malignancies.