Details

Autor(en) / Beteiligte

• Koch, W J
• Lefkowitz, R J
• Rockman, H A

Titel

Functional consequences of altering myocardial adrenergic receptor signaling

Ist Teil von

• Annual review of physiology, 2000-01, Vol.62 (1), p.237-260

Ort / Verlag

United States: Annual Reviews, Inc

Erscheinungsjahr

2000

Quelle

MEDLINE

Beschreibungen/Notizen

• From the ability to successfully manipulate the mouse genome has come important transgenic and gene-targeted knockout models that impact many areas of biomedical research. Genetically engineered mouse models geared toward the study of cardiovascular regulation have recently been described and provide powerful tools to study normal and compromised cardiac physiology. The genetic manipulation of the adrenergic receptor (AR) signaling system in the heart, including its regulation by desensitizing kinases, has shed light on the role of this signaling pathway in the regulation of cardiac contractility. One major finding, supported by several mouse models, is that in vivo contractility can be enhanced via alteration of myocardial AR signaling. Thus genetic manipulation of this critical receptor system in the heart represents a novel therapeutic approach for improving function of the failing heart.