Human molecular genetics, 2001-08, Vol.10 (17), p.1847-1851
2001
Details
- Autor(en) / Beteiligte
- Titel
- α-synuclein gene haplotypes are associated with Parkinson's disease
- Ist Teil von
- Human molecular genetics, 2001-08, Vol.10 (17), p.1847-1851
- Ort / Verlag
- Oxford: Oxford University Press
- Erscheinungsjahr
- 2001
- Link zum Volltext
- Quelle
- Oxford Journals 2020 Medicine
- Beschreibungen/Notizen
- We report haplotype analysis of the alpha-synuclein gene in Parkinson's disease (PD), extending earlier reports of an association with a polymorphism within the gene promoter. This analysis showed significant differences in haplotypes between PD cases and controls. Our analyses demonstrate that genetic variability in the alpha-synuclein gene is a risk factor for the development of PD. These genetic findings are analogous to the tau haplotype over-represented in progressive supranuclear palsy and further extend the similarity in the etiologies and pathogeneses of the synucleinopathies and tauopathies.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0964-6906, 1460-2083eISSN: 1460-2083DOI: 10.1093/hmg/10.17.1847Titel-ID: cdi_proquest_miscellaneous_71140482
- Format
- –
- Schlagworte
- a-Synuclein, Adult, Aged, Aged, 80 and over, alpha-Synuclein, Biological and medical sciences, Female, Fundamental and applied biological sciences. Psychology, Genetic Variation, Haplotypes, Humans, Male, Middle Aged, Molecular and cellular biology, Mutation, Nerve Tissue Proteins - genetics, Parkinson Disease - etiology, Parkinson Disease - genetics, Polymorphism, Genetic - genetics, Promoter Regions, Genetic, Sequence Analysis, Protein, Synucleins