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Association between deficiency of mannose-binding lectin and severe infections after chemotherapy
Ist Teil von
The Lancet (British edition), 2001-08, Vol.358 (9282), p.637-638
Ort / Verlag
England: Elsevier Ltd
Erscheinungsjahr
2001
Link zum Volltext
Quelle
EBSCOhost Business Source Ultimate
Beschreibungen/Notizen
The plasma protein mannose-binding lectin (MBL) activates the complement system by binding to carbohydrate structures presented by microorganisms and thus could be an important component of the innate immune defence system. We measured MBL in patients with leukaemia who were scheduled to undergo chemotherapy (ie, a population especially susceptible to infection) and related the results to severity of infection after chemotherapy. We showed a significant association between low concentrations of MBL and serious infections related to chemotherapy (p<0·0001). These results suggest that increasing concentrations of MBL in patients having chemotherapy could reduce susceptibility to infection.