Details

Autor(en) / Beteiligte

• Hashemi, Farhad B.
• Ghassemi, Mahmood
• Faro, Sebastian
• Aroutcheva, Alla
• Spear, Gregory T.

Titel

Induction of Human Immunodeficiency Virus Type 1 Expression by Anaerobes Associated with Bacterial Vaginosis

Ist Teil von

• The Journal of infectious diseases, 2000-05, Vol.181 (5), p.1574-1580

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

2000

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Bacterial vaginosis (BV) is a common disorder characterized by increased levels of anaerobic bacteria in the genital tract. BV has been associated with an increased rate of sexual transmission of human immunodeficiency virus (HIV). The effects of BV—associated anaerobic bacteria on HIV expression in monocytoid cells and T cells were examined. Peptostreptococcus asaccharolyticus and Prevotella bivia stimulated HIV expression in monocytoid cells, whereas Bacteroides ureolyticus, Peptostreptococcus anaerobius, and Lactobacillus acidophilus did not enhance HIV expression. P. asaccharolyticus also enhanced HIV expression in T cells and activated HIV long-terminal-repeat transcription in U38 cells. This report suggests a mechanism by which disturbances in vaginal flora could lead to a higher rate of sexual transmission of HIV. Furthermore, this study supports the idea that treatment of BV might serve as a preventive measure to reduce the risk of HIV transmission.