Molecular cell, 2001-03, Vol.7 (3), p.451-460
2001
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- Autor(en) / Beteiligte
- Titel
- The C. elegans E2F- and DP-Related Proteins Are Required for Embryonic Asymmetry and Negatively Regulate Ras/MAPK Signaling
- Ist Teil von
- Molecular cell, 2001-03, Vol.7 (3), p.451-460
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2001
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Early C. elegans embryos exhibit protein asymmetries that allow rapid diversification of cells. Establishing these asymmetries requires the novel protein MEX-5. We show that mutations in the efl-1 and dpl-1 genes cause defects in protein localization resembling defects caused by mutations in mex-5. efl-1 and dpl-1 encode homologs of vertebrate E2F and DP proteins that regulate transcription as a heterodimer. efl-1 and dpl-1 mutants have elevated levels of activated Map kinase in oocytes. Their mutant phenotype and that of mex-5 mutants can be suppressed by reducing Ras/Map kinase signaling. We propose this signaling pathway has a role in embryonic asymmetry and that EFL-1/DPL-1 control the level of Map kinase activation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1097-2765eISSN: 1097-4164DOI: 10.1016/S1097-2765(01)00193-9Titel-ID: cdi_proquest_miscellaneous_71123500
- Format
- –
- Schlagworte
- Animals, Body Patterning - genetics, Caenorhabditis elegans, Caenorhabditis elegans - cytology, Caenorhabditis elegans - embryology, Caenorhabditis elegans - genetics, Caenorhabditis elegans - metabolism, Caenorhabditis elegans Proteins, Carrier Proteins - genetics, Carrier Proteins - metabolism, Cell Cycle Proteins, Cell Division, Dimerization, DNA-Binding Proteins, DP protein, dpl-1 gene, DPL-1 protein, E2F protein, E2F Transcription Factors, efl-1 gene, EFL-1 protein, Enzyme Activation, Female, Fertilization - genetics, Genes, Helminth - genetics, Helminth Proteins - genetics, Helminth Proteins - metabolism, MAP Kinase Signaling System, mex-5 gene, MEX-5 protein, Mitogen-Activated Protein Kinases - antagonists & inhibitors, Mitogen-Activated Protein Kinases - metabolism, Mosaicism - genetics, Mutation - genetics, Ovulation - genetics, Ovum - metabolism, Phenotype, Protein Transport, ras Proteins - antagonists & inhibitors, ras Proteins - metabolism, Signal Transduction, Transcription Factors - genetics, Transcription Factors - metabolism