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Long-term effect of epalrestat, an aldose reductase inhibitor, on the development of incipient diabetic nephropathy in Type 2 diabetic patients
Ist Teil von
Journal of diabetes and its complications, 2001-09, Vol.15 (5), p.241-244
Ort / Verlag
New York, NY: Elsevier Inc
Erscheinungsjahr
2001
Link zum Volltext
Quelle
EZB-NALI5-00465 Elsevier Archive NL
Beschreibungen/Notizen
The aim of the present study was to elucidate the long-term effect of epalrestat, an aldose reductase inhibitor (ARI), on renal function in patients with type 2 diabetes mellitus showing microalbuminuria. Patients were allocated to two groups (cases and controls) matched for age, BMI, and the extent of urinary albumin excretion (UAE). Thirty-five type 2 diabetic patients presenting microalbuminuria were included in this study: cases were treated with epalrestat (150 mg/day) for 5 years. No significant changes were found in blood pressure, HbA1c, and total cholesterol in either group during the observation period. In the control group, UAE increased significantly (
P<.01) from 82±12 mg/g Cr at the baseline to 301±111 mg/g Cr at the end of the study, while UAE remained unchanged, 81±15 mg/g Cr at the baseline and 87±19 mg/g Cr at the end of the study, in the epalrestat-treated group. Reciprocal creatinine measured by an enzyme assay decreased significantly (
P<.01) in both groups; however, the reduction rate in the epalrestat-treated group was significantly (
P<.05) smaller than that in the control group. These results suggest the potential usefulness of ARIs in preventing the progression of incipient diabetic nephropathy in patients with type 2 diabetes mellitus.