Details

Autor(en) / Beteiligte

• WANG-GOHRKE, S
• CHANG-CLAUDE, J
• BECHER, H
• KIEBACK, D. G
• RUNNEBAUM, I. B

Titel

Progesterone receptor gene polymorphism is associated with decreased risk for breast cancer by age 50

Ist Teil von

• Cancer research (Chicago, Ill.), 2000-05, Vol.60 (9), p.2348-2350

Ort / Verlag

Philadelphia, PA: American Association for Cancer Research

Erscheinungsjahr

2000

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• In a population-based case-control study for breast cancer before the age of 51 years, 554 cases and 559 age-matched controls were genotyped for the polymorphic progesterone receptor allele PROGINS. Breast cancer risk was decreased in women carrying the PROGINS allele. The odds ratio adjusted for age and study region was 0.76 [95% confidence interval (CI), 0.58-1.00]. Compared with wild-type A1/A1 homozygotes, the odds ratio for A1/A2 heterozygotes and A2/A2 homozygotes was 0.82 (95% CI, 0.62-1.08) and 0.27 (95% CI, 0.10-0.74), respectively, suggesting a gene dosage effect of the A2 allele. There was suggestive evidence for a differential effect by menopausal status (P = 0.07) and by family history of breast cancer (P = 0.15).