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Seminars in cancer biology, 2001-08, Vol.11 (4), p.277-283
Ort / Verlag
Amsterdam: Elsevier Ltd
Erscheinungsjahr
2001
Link zum Volltext
Quelle
Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
Beschreibungen/Notizen
A B cell lymphoma model of dormancy in mice was established by prior immunization to the B cell membrane immunoglobulin idiotype. The antibody to the idiotype was the major factor in inducing and maintaining dormancy and acted primarily as an agonist rather than via effector functions. CD8+T cells synergized with anti-Id in inducing dormancy by secreting IFN γ. Cycling in the dormant population was reduced 3– 5 fold, but each mouse contained approximately 106tumor cells in its spleen, some of which were cycling, during the 1.5 years of observation. Thus, replication is balanced by cell death.