Details

Autor(en) / Beteiligte

• Wilton, L. A. K
• Baird, A. L
• Muir, Janice L
• Honey, R. C
• Aggleton, John P

Titel

Loss of the Thalamic Nuclei for "Head Direction" Impairs Performance on Spatial Memory Tasks in Rats

Ist Teil von

• Behavioral neuroscience, 2001-08, Vol.115 (4), p.861-869

Ort / Verlag

Washington, DC: American Psychological Association

Erscheinungsjahr

2001

Quelle

MEDLINE

Beschreibungen/Notizen

• This study sought to characterize the effects of removing the nuclei of primary importance in relaying the thalamic head direction signal to the hippocampal formation (the anterior dorsal [AD] and lateral dorsal [LD] nuclei) on the performance of a variety of spatial and nonspatial tasks. The results indicate that combined excitotoxic lesions of the AD and LD nuclei produce marked deficits on a variety of spatial tasks. These tasks included T -maze alternation and the ability to locate a hidden platform set at a fixed distance and fixed direction from a beacon in a Morris water maze. Although object recognition appeared unaffected, marked impairments were found in the ability to detect when an object was placed in a novel position (object-in-place memory).