Details

Autor(en) / Beteiligte

• Liu, Ho-Ling
• Pu, Yonglin
• Nickerson, Lisa D.
• Liu, Yijun
• Fox, Peter T.
• Gao, Jia-Hong

Titel

Comparison of the temporal response in perfusion and BOLD-based event-related functional MRI

Ist Teil von

• Magnetic resonance in medicine, 2000-05, Vol.43 (5), p.768-772

Ort / Verlag

New York: John Wiley & Sons, Inc

Erscheinungsjahr

2000

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Event‐related functional MRI (ER‐fMRI) based on both blood oxygen level‐dependent (BOLD) contrast and perfusion contrast has been recently developed to study human brain activation due to brief stimulation. In this report, both BOLD‐ and perfusion‐based ER‐fMRI were directly compared using repeated single‐trial, short visual stimulation (1 sec) in six human volunteers. The results show that the cerebral blood flow change reached a maximum approximately 1 sec earlier than the BOLD signal change (4.2 ± 0.2 sec vs. 5.1 ± 0.2 sec after the stimulation, P < 0.05). The full width at half maximum of the hemodynamic response measured by perfusion was not significantly different from that measured with BOLD (5.1 ± 0.6 sec vs. 5.9 ± 0.6 sec). A positive linear correlation was found between the maximum perfusion and maximum BOLD signal changes (r = 0.77, P = 0.07). Magn Reson Med 43:768–772, 2000. © 2000 Wiley‐Liss, Inc.