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Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat
Ist Teil von
Nature genetics, 2000-05, Vol.25 (1), p.87-90
Ort / Verlag
London: Nature Publishing Group
Erscheinungsjahr
2000
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Triglycerides (or triacylglycerols) represent the major form of stored
energy in eukaryotes. Triglyceride synthesis has been assumed to occur primarily
through acyl CoA:diacylglycerol transferase (Dgat), a microsomal enzyme that
catalyses the final and only committed step in the glycerol phosphate pathway. Therefore, Dgat has been considered necessary for adipose
tissue formation and essential for survival. Here we show that Dgat-deficient
(Dgat−/−) mice are viable and can still
synthesize triglycerides. Moreover, these mice are lean and resistant to diet-induced
obesity. The obesity resistance involves increased energy expenditure and
increased activity. Dgat deficiency also alters triglyceride metabolism in
other tissues, including the mammary gland, where lactation is defective in
Dgat−/− females. Our findings indicate that
multiple mechanisms exist for triglyceride synthesis and suggest that the
selective inhibition of Dgat-mediated triglyceride synthesis may be useful
for treating obesity.