Psychoneuroendocrinology, 2001-10, Vol.26 (7), p.751-756
2001
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Details
- Autor(en) / Beteiligte
- Titel
- Impact of cortisol on buspirone stimulated prolactin release: a double-blind placebo-controlled study
- Ist Teil von
- Psychoneuroendocrinology, 2001-10, Vol.26 (7), p.751-756
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2001
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- Buspirone is known to stimulate prolactin release. Clinical studies (e.g. in chronic fatigue syndrome) suggest that the response may be influenced by baseline cortisol levels. We conducted a double-blind placebo-controlled study to examine the relationship between the prolactin response to buspirone challenge and baseline cortisol level. Fifty healthy volunteers took part in the study. Buspirone was found to consistently elevate PRL levels above those seen following placebo administration. The PRL response as measured by area under the curve was highly correlated with the baseline cortisol level.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-4530eISSN: 1873-3360DOI: 10.1016/S0306-4530(01)00029-4Titel-ID: cdi_proquest_miscellaneous_71086872
- Format
- –
- Schlagworte
- 5HT, Adult, Behavioral psychophysiology, Biological and medical sciences, Buspirone, Buspirone - pharmacology, Cortisol, Double-Blind Method, Female, Fundamental and applied biological sciences. Psychology, Hormones and behavior, Humans, Hydrocortisone - blood, Hydrocortisone - pharmacology, Male, Middle Aged, Placebo-control, Prolactin, Prolactin - blood, Prolactin - metabolism, Psychology. Psychoanalysis. Psychiatry, Psychology. Psychophysiology, Serotonin Receptor Agonists - pharmacology, Sex Characteristics