Biochemical and biophysical research communications, 2001-08, Vol.286 (2), p.239-242
2001
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Details
- Autor(en) / Beteiligte
- Titel
- The Effect of Dexamethasone on P450 Activities in Regenerating Rat Liver
- Ist Teil von
- Biochemical and biophysical research communications, 2001-08, Vol.286 (2), p.239-242
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2001
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- The aim of our study was to detect four P450s (CYP1A, CYP2B, CYP2E1, CYP3A) on the basis of selective enzyme activities and protein amount, and to investigate the effect of dexamethasone treatment during liver regeneration. Partial hepatectomy of rats resulted in the loss of CYP1A, CYP2B, CYP2E1, and CYP3A activities. The reduction of enzyme activities and the loss of enzyme protein of CYP2B1/2, CYP2E1, and CYP3A1/2 were the most pronounced. In the case of CYP1A1, only slight decrease was observed. Dexamethasone treatment seems to counteract this loss mainly in the first 12 h.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0006-291XeISSN: 1090-2104DOI: 10.1006/bbrc.2001.5341Titel-ID: cdi_proquest_miscellaneous_71085981
- Format
- –
- Schlagworte
- Animals, Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP2B1 - metabolism, Cytochrome P-450 CYP2E1 - metabolism, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme System - metabolism, cytochrome P450, dexamethasone, Dexamethasone - pharmacology, Hepatectomy, Kinetics, Liver - drug effects, Liver - enzymology, liver regeneration, Liver Regeneration - drug effects, Mixed Function Oxygenases - metabolism, Rats, Steroid Hydroxylases - metabolism