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Acetylcholine Affects the Spatial Scale of Attention: Evidence From Alzheimer's Disease
Ist Teil von
Neuropsychology, 2000-04, Vol.14 (2), p.288-298
Ort / Verlag
Washington, DC: American Psychological Association
Erscheinungsjahr
2000
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Location precues were used to manipulate the spatial scale
of attention in visual search for a target in an array of letters in
patients with dementia of the Alzheimer type (DAT) and in
age-matched older controls. Cue size varied in the amount of spatial
precision conferred. Scopolamine, a muscarinic antagonist, decreased
overall arousal and broadened spatial attention after a precise
precue (small and valid) to target location for DAT patients but not
for controls, suggesting a selective effect for attentional
impairment induced by cholinergic blockade. In contrast,physostigmine, a cholinesterase inhibitor, did not alter the
distribution of spatial attention relative to no-drug baseline
testing for patients. Results support a differential role for
cholinergic mechanisms in the modulation of the spatial scale of
visual attention.