Details

Autor(en) / Beteiligte

• AAEM Quality Assurance Committee. American Association of Electrodiagnostic Medicine

Titel

Literature review of the usefulness of repetitive nerve stimulation and single fiber EMG in the electrodiagnostic evaluation of patients with suspected myasthenia gravis or Lambert-Eaton myasthenic syndrome

Ist Teil von

• Muscle & nerve, 2001-09, Vol.24 (9), p.1239-1247

Ort / Verlag

New York: John Wiley & Sons, Inc

Erscheinungsjahr

2001

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• A retrospective literature review of the electrodiagnosis of myasthenia gravis (MG) and Lambert–Eaton myasthenic syndrome (LEMS) through July 1998 was performed for the purpose of generating evidence‐based practice parameters. There were 545 articles identified, of which 13 articles met at least three of the six criteria set previously by the American Association of Electrodiagnostic Medicine (AAEM). An additional 21 articles were identified from review articles or the references of these first 13 articles leading to a total of 34 articles. Results of studies utilizing repetitive nerve stimulation (RNS) showed that a 10% decrement in amplitude from the first to fourth or fifth intravolley waveform while stimulating at 2–5 HZ is valid for the diagnosis of MG. The degree of increment needed for the diagnosis of LEMS is at least 25% but most accurate when greater than 100%. Abnormal jitter or impulse blocking are the appropriate criteria for diagnosis of neuromuscular junction (NMJ) disorders when using single fiber electromyography (SFEMG). SFEMG is more sensitive than RNS for the diagnosis of disorders of neuromuscular transmission, but may be less specific and may not be available. Therefore, RNS remains the preferred initial test for MG and LEMS. © 2001 American Association of Electrodiagnostic Medicine Muscle Nerve 24: 1239–1247, 2001