Details

Autor(en) / Beteiligte

• Kim, Hyoung-Chun
• Bing, Guoying
• Shin, Eun-Joo
• Jhoo, Hyun-Seon
• Cheon, Mi-Ae
• Lee, Seung-Hyun
• Choi, Ki Hwan
• Kim, Joo Il
• Jhoo, Wang-Kee

Titel

Dextromethorphan affects cocaine-mediated behavioral pattern in parallel with a long-lasting Fos-related antigen-immunoreactivity

Ist Teil von

• Life sciences (1973), 2001-06, Vol.69 (6), p.615-624

Ort / Verlag

Netherlands: Elsevier Inc

Erscheinungsjahr

2001

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• In order to understand the underlying mechanisms responsible for the behaviors mediated by dextromethorphan (DM), we examined the effects of DM on locomotor activity and locomotor patterns in mice, and Fos-related antigen immunoreactivity (FRA-IR) of mouse brain following repeated administration of cocaine. Combined treatments (30 min prior to each cocaine administration) with DM dose-dependently decreased locomotor activity for high doses of cocaine (20 mg/kg, i.p./day × 7). DM combinations did not significantly affect hyperactivity for 10 mg cocaine/kg, i.p./day × 7. In contrast, combined treatments with DM increased the locomotor activity for 5 mg cocaine/kg, i.p./day × 7. These results were consistent with alterations in marginal activity. Repeated administration with cocaine or DM increased FRA-IR in the nucleus accumbens (NAc) and striatum which lasted for at least 7 days. Our results suggest that DM exhibits biphasic effects on the locomotor stimulation induced by cocaine, and that locomotor activities are in parallel with FRA-IR of the striatal complex. However, the role of FRA-IR regulated by DM or/and cocaine remains to be further determined.