Details

Autor(en) / Beteiligte

• McMahon, Blaithin
• Mitchell, Siobhan
• Brady, Hugh R.
• Godson, Catherine

Titel

Lipoxins: revelations on resolution

Ist Teil von

• Trends in pharmacological sciences (Regular ed.), 2001-08, Vol.22 (8), p.391-395

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2001

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Lipoxins (LXs) are endogenously produced eicosanoids typically generated during cell–cell interactions. In this article, the compelling evidence from in vitro and in vivo model systems that LXs actively promote the resolution of inflammation is reviewed. Of particular interest are indications that stable synthetic analogues of LXs and aspirin-triggered 15-epi-LXs can mimic many of the desirable anti-inflammatory, ‘pro-resolution’ actions of native LXs. Given the enhanced stability and efficacy of these compounds a role as novel anti-inflammatory therapeutics is proposed.