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Trends in pharmacological sciences (Regular ed.), 2001-08, Vol.22 (8), p.391-395
Ort / Verlag
England: Elsevier Ltd
Erscheinungsjahr
2001
Quelle
Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
Beschreibungen/Notizen
Lipoxins (LXs) are endogenously produced eicosanoids typically generated during cell–cell interactions. In this article, the compelling evidence from
in vitro and
in vivo model systems that LXs actively promote the resolution of inflammation is reviewed. Of particular interest are indications that stable synthetic analogues of LXs and aspirin-triggered 15-epi-LXs can mimic many of the desirable anti-inflammatory, ‘pro-resolution’ actions of native LXs. Given the enhanced stability and efficacy of these compounds a role as novel anti-inflammatory therapeutics is proposed.