Microbes and infection, 2000-03, Vol.2 (3), p.295-304
2000
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Details
- Autor(en) / Beteiligte
- Titel
- CD14, new aspects of ligand and signal diversity
- Ist Teil von
- Microbes and infection, 2000-03, Vol.2 (3), p.295-304
- Ort / Verlag
- France: Elsevier SAS
- Erscheinungsjahr
- 2000
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- The glycosyl-phosphatidylinositol-linked glycoprotein CD14 is expressed in myeloid cells and serum. It binds Gram-negative and -positive bacterial cell wall components and endogenous phospholipids. Toll-like receptors, NF-κB and MAP kinases participate in CD14 signaling of inflammation. Alterations of CD14 in inflammatory diseases support a pathogenic role for this microbial receptor.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1286-4579eISSN: 1769-714XDOI: 10.1016/S1286-4579(00)00298-7Titel-ID: cdi_proquest_miscellaneous_71029640
- Format
- –
- Schlagworte
- Animals, CD14, CD14 antigen, Cell Membrane - immunology, CHO Cells, Cricetinae, Drosophila Proteins, Humans, Leukocytes - immunology, Ligands, lipopolysaccharide, Lipopolysaccharide Receptors - genetics, Lipopolysaccharide Receptors - immunology, Lipopolysaccharide Receptors - metabolism, Lipopolysaccharides - immunology, Macrophages - immunology, Membrane Glycoproteins - immunology, NF-^KB protein, Receptors, Cell Surface - immunology, Shock, Septic - immunology, Signal Transduction - immunology, signaling, Systemic Inflammatory Response Syndrome - immunology, Toll-Like Receptors