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PSA based review of adjuvant and salvage radiation therapy vs. observation in postoperative prostate cancer patients
International journal of cancer, 2000-02, Vol.90 (1), p.29-36
Peschel, Richard E.
Robnett, Theodore J.
Hesse, David
King, Christopher R.
Ennis, Ronald D.
Schiff, Peter B.
Wilson, Lynn D.
2000
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Peschel, Richard E.
Robnett, Theodore J.
Hesse, David
King, Christopher R.
Ennis, Ronald D.
Schiff, Peter B.
Wilson, Lynn D.
Titel
PSA based review of adjuvant and salvage radiation therapy vs. observation in postoperative prostate cancer patients
Ist Teil von
International journal of cancer, 2000-02, Vol.90 (1), p.29-36
Ort / Verlag
New York: John Wiley & Sons, Inc
Erscheinungsjahr
2000
Quelle
Electronic Journals Library
Beschreibungen/Notizen
Because of the uncertainties regarding the efficacy of postoperative radiation therapy for early prostate cancer, treatment strategies following radical prostatectomy include: (1) observation alone in high‐risk patients, (2) adjuvant radiation therapy (PSA undetectable) in high‐risk patients, or (3) salvage radiation therapy for biochemical and clinical recurrence. Fifty‐two patients treated with postoperative radiation therapy in either an adjuvant setting (13) or for salvage (39) were retrospectively reviewed. The actuarial biochemical disease‐free survival (bNED) rates following radiation therapy were calculated using the life‐table method. Univariate and multi variate analyses were used to define the clinical factors that predict biochemical failure following postoperative radiation therapy. In addition, the bNED survival rate for 36 high‐risk surgery patients who were simply observed following prostatectomy was determined. The 3‐year bNED survival rate for the adjuvant radiation group was 85% compared with 27% for salvage radiation and 43% for the observation group. These results are statistically significant. Factors that predict biochemical failure following postoperative radiation therapy include preoperative PSA level, pre‐radiation therapy PSA level, and seminal vesicle involvement. At our institutions, adjuvant radiation therapy was a superior strategy compared with either observation alone or salvage radiation therapy for high‐risk postoperative prostate cancer patients. Int. J. Cancer (Radiat. Oncol. Invest.) 90, 29–36 (2000). © 2000 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0020-7136
eISSN: 1097-0215
DOI: 10.1002/(SICI)1097-0215(20000220)90:1<29::AID-IJC4>3.0.CO;2-5
Titel-ID: cdi_proquest_miscellaneous_70970910
Format
–
Schlagworte
Aged
,
Analysis of Variance
,
Biological and medical sciences
,
Genital system. Mammary gland
,
Humans
,
Male
,
Medical sciences
,
Middle Aged
,
Neoplasm Proteins - blood
,
Neoplasm Recurrence, Local - blood
,
Postoperative Period
,
postoperative radiation therapy
,
prostate cancer
,
Prostate-Specific Antigen - blood
,
Prostatectomy
,
Prostatic Neoplasms - blood
,
Prostatic Neoplasms - radiotherapy
,
Prostatic Neoplasms - surgery
,
Radiotherapy, Adjuvant
,
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
,
Regression Analysis
,
Retrospective Studies
,
salvage radiation therapy
,
Salvage Therapy
,
Survival Rate
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