Details

Autor(en) / Beteiligte

• Karlon, William J
• McCulloch, Andrew D
• Covell, James W
• Hunter, John J
• Omens, Jeffrey H

Titel

Regional dysfunction correlates with myofiber disarray in transgenic mice with ventricular expression of ras

Ist Teil von

• American journal of physiology. Heart and circulatory physiology, 2000-03, Vol.278 (3), p.H898-H906

Ort / Verlag

United States

Erscheinungsjahr

2000

Quelle

MEDLINE

Beschreibungen/Notizen

• 1  Department of Bioengineering and 2  Department of Medicine, University of California San Diego, La Jolla, California 92093 A hallmark of certain cardiac diseases such as familial hypertrophic cardiomyopathy is focal myofiber disarray. Regional ventricular dysfunction occurs in human subjects with hypertrophic cardiomyopathy; however, no direct evidence exists to correlate regional dysfunction with myofiber disarray. We used a transgenic mouse, which exhibits regional myofiber disarray via ventricular expression of the human oncogene ras, to investigate the relationship between myofiber disarray and septal surface strain. An isolated ejecting mouse heart preparation was used to record deformation of markers on the septal surface and to determine nonhomogeneous septal surface strain maps. Myofiber disarray made in histological tissue sections was correlated with gradients in surface systolic shortening. Significantly smaller maximum principal shortening was associated with disarray located near the right ventricle (RV) septal surface. There was also significantly smaller surface shear strain associated with disarray located either near the RV surface or at the midwall. Because surface shear is a local indicator of torsion, we conclude that myofiber disarray is associated with reduced septal torsion and reduced surface shortening. hypertrophic cardiomyopathy; fiber angle; surface strain; ventricular torsion