Details

Autor(en) / Beteiligte

• Kim, Jung Han
• Sen, Śaunak
• Avery, Cindy S.
• Simpson, Elizabeth
• Chandler, Phillip
• Nishina, Patsy M.
• Churchill, Gary A.
• Naggert, Jürgen K.

Titel

Genetic Analysis of a New Mouse Model for Non-Insulin-Dependent Diabetes

Ist Teil von

• Genomics (San Diego, Calif.), 2001-06, Vol.74 (3), p.273-286

Ort / Verlag

San Diego, CA: Elsevier Inc

Erscheinungsjahr

2001

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• The TallyHo (TH) mouse strain is a newly established model for non-insulin-dependent diabetes mellitus(NIDDM). TH mice show obesity, hyperinsulinemia, hyperlipidemia, and male-limited hyperglycemia. A genetic dissection of the diabetes syndrome has been carried out using male backcross 1 progeny obtained from crosses between (C57BL/6J × TH)F1 and TH mice or (CAST/Ei × TH)F1 and TH mice. A genome-wide scan reveals three quantitative trait loci (QTLs), Tanidd1–3 (TH-associated NIDDM) linked to hyperglycemia. The major QTL (common in both crosses), Tanidd1, maps to chromosome (Chr) 19. Additionally, gene–gene interactions contributing to hyperglycemia have been observed between Tanidd1 and a locus on Chr 18 as well as between Tanidd2 and a locus on Chr 16. The overt hyperglycemia in TH mice is, therefore, likely due to a mutation in a major diabetes susceptibility locus on Chr 19, which interacts with additional genes to lead to an observable phenotype.