Farmaco (Società chimica italiana : 1989), 2001-04, Vol.56 (4), p.311-318
2001
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Details
- Autor(en) / Beteiligte
- Titel
- Synthesis and antiplatelet activity of some 2,7-di( N-cycloamino)-3-phenyl-1,8-naphthyridine derivatives
- Ist Teil von
- Farmaco (Società chimica italiana : 1989), 2001-04, Vol.56 (4), p.311-318
- Ort / Verlag
- Lausanne: Elsevier SAS
- Erscheinungsjahr
- 2001
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Several 2,7-di( N-cycloamino)-3-phenyl-1,8-naphthyridine derivatives were synthesized and tested for their ability to inhibit human platelet aggregation in vitro induced by arachidonic acid, collagen and ADP. Only five compounds showed any appreciable activity, and the results of all the active derivatives were similar to those of papaverine in the test with arachidonic acid and collagen. Moreover, the most active compounds were investigated in the test with ADP and again showed a significant activity. The tested compounds that possessed the best activity were also shown to increase the c-AMP level significantly without involving the adenylyl cyclase system.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-827XeISSN: 1879-0569DOI: 10.1016/S0014-827X(01)01075-8Titel-ID: cdi_proquest_miscellaneous_70942237
- Format
- –
- Schlagworte
- 2,7-Di( N-cycloamino)-3-phenyl-1,8-naphthyridine, Adenosine Diphosphate - antagonists & inhibitors, Adenosine Diphosphate - pharmacology, Arachidonic Acid - antagonists & inhibitors, Arachidonic Acid - pharmacology, Biological and medical sciences, Blood Platelets - drug effects, Blood Platelets - metabolism, Blood. Blood coagulation. Reticuloendothelial system, Chemical Phenomena, Chemistry, Physical, Collagen - antagonists & inhibitors, Collagen - pharmacology, Cyclic AMP - blood, Human blood platelets, Humans, In Vitro Techniques, Indicators and Reagents, Inhibition of platelet aggregation, Magnetic Resonance Spectroscopy, Medical sciences, Morpholinyl, Naphthyridines - chemical synthesis, Naphthyridines - pharmacology, Pharmacology. Drug treatments, Piperazinyl, Piperidinyl, Platelet Aggregation - drug effects, Platelet Aggregation Inhibitors - chemical synthesis, Platelet Aggregation Inhibitors - pharmacology, Spectrophotometry, Infrared, Structure-Activity Relationship