Details

Autor(en) / Beteiligte

• Willoughby, Derek A
• Moore, Adrian R
• Colville-Nash, Paul R

Titel

COX-1, COX-2, and COX-3 and the future treatment of chronic inflammatory disease

Ist Teil von

• The Lancet (British edition), 2000-02, Vol.355 (9204), p.646-648

Ort / Verlag

London: Elsevier Ltd

Erscheinungsjahr

2000

Quelle

Psychology & Behavioral Sciences Collection

Beschreibungen/Notizen

• A new generation of non-steroidal anti-inflammatory drugs has been described that selectively targets the inducible isoform of cyclo-oxygenase, cyclo-oxygenase 2 (COX-2). This isoform is expressed at sites of inflammation, which has led to the speculation that its inhibition could provide all the benefits of current nonsteroidal anti-inflammatory drugs, but without their major side-effects on the gastrointestinal system (which are due to inhibition of COX-1). We have shown that COX-2 (identified by use of specific antibodies) is induced during the resolution of an inflammatory response, inhibition of COX-2 resulting in persistence of the inflammation due to the prevention of the synthesis of a range of anti-inflammatory prostanoids. We propose that there is a third isoform of this enzyme family, COX-3, a proposal that will have implication for the prescription of both existing and new generation anti-inflammatory drugs, and might represent a new therapeutic target.