Details

Autor(en) / Beteiligte

• Harrison, G.
• Hopper, K.
• Craig, T.
• Laska, E.
• Siegel, C.
• Wanderling, J.
• Dube, K. C.
• Ganev, K.
• Giel, R.
• Der Heiden, W. An
• Holmberg, S. K.
• Janca, A.
• Lee, P. W. H.
• León, C. A.
• Malhotra, S.
• Marsella, A. J.
• Nakane, Y.
• Sartorius, N.
• Shen, Y.
• Skoda, C.
• Thara, R.
• Tsirkin, S. J.
• Varma, V. K.
• Walsh, D.
• Wiersma, D.

Titel

Recovery from psychotic illness: A 15- and 25-year international follow-up study

Ist Teil von

• British journal of psychiatry, 2001-06, Vol.178 (6), p.506-517

Ort / Verlag

Cambridge, UK: Cambridge University Press

Erscheinungsjahr

2001

Quelle

Applied Social Sciences Index & Abstracts (ASSIA)

Beschreibungen/Notizen

• Poorly defined cohorts and weak study designs have hampered cross-cultural comparisons of course and outcome in schizophrenia. To describe long-term outcome in 18 diverse treated incidence and prevalence cohorts. To compare mortality, 15- and 25-year illness trajectory and the predictive strength of selected baseline and short-term course variables. Historic prospective study. Standardised assessments of course and outcome. About 75% traced. About 50% of surviving cases had favourable outcomes, but there was marked heterogeneity across geographic centres. In regression models, early (2-year) course patterns were the strongest predictor of 15-year outcome, but recovery varied by location; 16% of early unremitting cases achieved late-phase recovery. A significant proportion of treated incident cases of schizophrenia achieve favourable long-term outcome. Sociocultural conditions appear to modify long-term course. Early intervention programmes focused on social as well as pharmacological treatments may realise longer-term gains.