Journal of medicinal chemistry, 2001-06, Vol.44 (13), p.2061-2064
2001
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Details
- Autor(en) / Beteiligte
- Titel
- Design and synthesis of 2-methyl-2-[4-(2-[5-methyl-2-aryloxazol-4-yl]ethoxy)phenoxy]propionic acids: a new class of dual PPARalpha/gamma agonists
- Ist Teil von
- Journal of medicinal chemistry, 2001-06, Vol.44 (13), p.2061-2064
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2001
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Propionic acid derivative 8, which was designed and synthesized based on putative pharmacophores of known PPARgamma- and PPARalpha-selective compounds, exhibits potent dual PPARalpha/gamma agonist activity as demonstrated by in vitro binding and dose overlap in the newly introduced EOB mouse model for glucose lowering and lipid/cholesterol homeostasis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-2623Titel-ID: cdi_proquest_miscellaneous_70933560
- Format
- –
- Schlagworte
- Animals, Blood Glucose - metabolism, Cholesterol, HDL - blood, Diabetes Mellitus - blood, Diabetes Mellitus - drug therapy, Diabetes Mellitus - genetics, Diabetes Mellitus, Type 2 - drug therapy, Drug Design, Hypoglycemic Agents - chemical synthesis, Hypoglycemic Agents - pharmacology, Mice, Mice, Inbred Strains, Propionates - chemical synthesis, Propionates - pharmacology, Receptors, Cytoplasmic and Nuclear - agonists, Receptors, Cytoplasmic and Nuclear - genetics, Transcription Factors - agonists, Transcription Factors - genetics, Triglycerides - blood