Details

Autor(en) / Beteiligte

• Sauerbronn, A.V.D
• Fonseca, A.M
• Bagnoli, V.R
• Saldiva, P.H
• Pinotti, J.A

Titel

The effects of systemic hormonal replacement therapy on the skin of postmenopausal women

Ist Teil von

• International journal of gynecology and obstetrics, 2000, Vol.68 (1), p.35-41

Ort / Verlag

Shannon: Elsevier Ireland Ltd

Erscheinungsjahr

2000

Quelle

Wiley Blackwell Single Titles

Beschreibungen/Notizen

• Objective: The aim of this study was to determine the effects of hormonal replacement therapy on the skin of postmenopausal women. Method: Forty-one postmenopausal women were randomly allocated to receive either hormonal replacement (valerate estradiol — 2 mg/day for 21 days and cyproterone acetate — 1 mg/day for 10 days) or placebo, both in a cyclic scheme for 6 months. Neither patients nor investigators were aware of the group allocation. Histologic changes were evaluated by skin biopsy of the left upper arm at baseline and after 6 months of treatment, utilizing computerized image analysis to assess the ratio area of epidermis/basement membrane length (AE/BML), ratio area of keratin/basement membrane length (AK/BML) and collagen and elastic fibers content. Result: Collagen content of the left upper arm increased after 6 months of treatment only in the hormonal group (+6.49%; P<0.05). Other parameters did not present any significant alteration after treatment in both groups. Conclusion: Hormonal replacement for climacterics increases skin collagen content.