Details

Autor(en) / Beteiligte

• KRIVAK, Thomas C
• MCBROOM, John W
• SEIDMAN, Jeffrey
• VENZON, David
• CROTHERS, Barbara
• MACKOUL, Paul J
• ROSE, G. Scott
• CARLSON, Jay W
• BIRRER, Michael J

Titel

Abnormal fragile histidine triad (FHIT) expression in advanced cervical carcinoma : A poor prognostic factor

Ist Teil von

• Cancer research (Chicago, Ill.), 2001-06, Vol.61 (11), p.4382-4385

Ort / Verlag

Philadelphia, PA: American Association for Cancer Research

Erscheinungsjahr

2001

Quelle

MEDLINE

Beschreibungen/Notizen

• The FHIT gene is a candidate tumor suppressor gene that has been implicated in the development of cervical carcinoma. We hypothesized that abnormal Fhit expression might be a poor prognostic factor for patients with cervical cancer. The tumors from 59 high-risk patients (stage II-III) were evaluated for abnormal Fhit expression by immunohistochemical staining. Abnormal Fhit expression (absent or reduced) was noted in 66% of the specimens. There was no statistical difference with respect to stage, performance status, para-aortic node metastasis, completion of therapy, grade, race, age, and HIV status between the normal and abnormal Fhit expression groups. The 3-year survival for patients whose tumors displayed normal Fhit expression versus abnormal Fhit expression was 74% versus 37%, respectively. Univariate analysis demonstrated a difference in survival that was statistically significant for age <55 years versus > or =55 years (P = 0.015), normal Fhit expression versus abnormal Fhit expression (P = 0.015), and stage II versus stage III (P = 0.033). Multivariate analysis showed that abnormal Fhit expression was a poor prognostic factor (P = 0.015).