Nature medicine, 2000-02, Vol.6 (2), p.151-158
2000
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- Autor(en) / Beteiligte
- Titel
- Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
- Ist Teil von
- Nature medicine, 2000-02, Vol.6 (2), p.151-158
- Ort / Verlag
- United States: Nature Publishing Group
- Erscheinungsjahr
- 2000
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Trypsin and mast cell tryptase cleave proteinase-activated receptor 2 and, by unknown mechanisms, induce widespread inflammation. We found that a large proportion of primary spinal afferent neurons, which express proteinase-activated receptor 2, also contain the proinflammatory neuropeptides calcitonin gene-related peptide and substance P. Trypsin and tryptase directly signal to neurons to stimulate release of these neuropeptides, which mediate inflammatory edema induced by agonists of proteinase-activated receptor 2. This new mechanism of protease-induced neurogenic inflammation may contribute to the proinflammatory effects of mast cells in human disease. Thus, tryptase inhibitors and antagonists of proteinase-activated receptor 2 may be useful anti-inflammatory agents.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1078-8956eISSN: 1546-170XDOI: 10.1038/72247Titel-ID: cdi_proquest_miscellaneous_70898812
- Format
- –
- Schlagworte
- Animals, Base Sequence, Calcitonin Gene-Related Peptide - metabolism, Chymases, DNA Probes, Ganglia, Spinal - metabolism, Ganglia, Spinal - pathology, Humans, Hybridization, In Situ Hybridization, Inflammation, Inflammation - etiology, Ligands, Localization, Male, Medicine, Neurons - metabolism, Neuropeptides, Peptides, Plasma, proteinase-activated receptor 2, Rats, Rats, Sprague-Dawley, Rats, Wistar, Receptor, PAR-2, Receptors, Thrombin - agonists, Receptors, Thrombin - metabolism, Serine Endopeptidases - metabolism, Signal Transduction, Small intestine, Substance P - metabolism, Trypsin - metabolism, Tryptases