Trends in neurosciences (Regular ed.), 2000-02, Vol.23 (2), p.80-88
2000
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- Autor(en) / Beteiligte
- Titel
- Complex interactions between mGluRs, intracellular Ca2+ stores and ion channels in neurons
- Ist Teil von
- Trends in neurosciences (Regular ed.), 2000-02, Vol.23 (2), p.80-88
- Ort / Verlag
- Oxford: Elsevier Science
- Erscheinungsjahr
- 2000
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- Metabotropic glutamate receptors (mGluRs) can increase intracellular Ca2+ concentration via Ins(1,4,5)P3- and ryanodine-sensitive Ca2+ stores in neurons. Both types of store are coupled functionally to Ca2+-permeable channels found in the plasma membrane. The mGluR-mediated increase in intracellular Ca2+ concentration can activate Ca2+-sensitive K+ channels and Ca2+-dependent nonselective cationic channels. These mGluR-mediated effects often result from mobilization of Ca2+ from ryanodine-sensitive, rather than Ins(1,4, 5)P3-sensitive, Ca2+ stores, suggesting that close functional interactions exist between mGluRs, intracellular Ca2+ stores and Ca2+-sensitive ion channels in the membrane.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0166-2236eISSN: 1878-108XDOI: 10.1016/s0166-2236(99)01492-7Titel-ID: cdi_proquest_miscellaneous_70890818
- Format
- –
- Schlagworte
- Animals, Biological and medical sciences, Calcium - metabolism, Calcium Channels - metabolism, Carrier Proteins - chemistry, Carrier Proteins - genetics, Carrier Proteins - metabolism, Fundamental and applied biological sciences. Psychology, General aspects. Models. Methods, Homer Scaffolding Proteins, Humans, Ion Channels - metabolism, Ions, Membranes, Neuronal Plasticity, Neurons, Neurons - metabolism, Neuropeptides - chemistry, Neuropeptides - genetics, Neuropeptides - metabolism, Plasma, Potassium Channels - metabolism, Receptors, Metabotropic Glutamate - metabolism, Ryanodine Receptor Calcium Release Channel - metabolism, Vertebrates: nervous system and sense organs