Annals of neurology, 2000-01, Vol.47 (1), p.127-131
2000
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Details
- Autor(en) / Beteiligte
- Titel
- Combination therapy with glatiramer acetate (copolymer-1) and a type I interferon (IFN-α) does not improve experimental autoimmune encephalomyelitis
- Ist Teil von
- Annals of neurology, 2000-01, Vol.47 (1), p.127-131
- Ort / Verlag
- New York: John Wiley & Sons, Inc
- Erscheinungsjahr
- 2000
- Quelle
- Access via Wiley Online Library
- Beschreibungen/Notizen
- We sought to determine whether combinations of glatiramer acetate and parenteral or ingested type I interferon were synergistic in experimental autoimmune encephalomyelitis. Glatiramer acetate, subcutaneous murine interferon‐α, or ingested murine interferon‐α individually improved clinical scores. In contrast, glatiramer acetate in conjunction with either subcutaneous or ingested interferon‐α did not improve clinical scores compared with control. These data suggest that clinical trials designed to test a possible synergistic effect of glatiramer acetate and type I interferon in humans should be designed to detect possible adverse effects of this combination of immunomodulatory agents. Ann Neurol 2000; 47:127–131
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0364-5134eISSN: 1531-8249DOI: 10.1002/1531-8249(200001)47:1<127::AID-ANA22>3.0.CO;2-1Titel-ID: cdi_proquest_miscellaneous_70886779
- Format
- –
- Schlagworte
- Animals, Biological and medical sciences, Dose-Response Relationship, Drug, Drug Therapy, Combination, Encephalomyelitis, Autoimmune, Experimental - drug therapy, Glatiramer Acetate, Immunomodulators, Immunosuppressive Agents - administration & dosage, Immunosuppressive Agents - therapeutic use, Interferon Type I - administration & dosage, Interferon Type I - therapeutic use, Medical sciences, Mice, Peptides - administration & dosage, Peptides - therapeutic use, Pharmacology. Drug treatments