Chemical and Pharmaceutical Bulletin, 2001, Vol.49(5), pp.652-654
2001
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- Autor(en) / Beteiligte
- Titel
- New Insulinomimetic Zinc(II) Complexes of α-Amino Acids and Their Derivatives with Zn(N2O2) Coordination Mode
- Ist Teil von
- Chemical and Pharmaceutical Bulletin, 2001, Vol.49(5), pp.652-654
- Ort / Verlag
- Tokyo: The Pharmaceutical Society of Japan
- Erscheinungsjahr
- 2001
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Zinc(II) complexes of α-amino acids and their derivatives with a Zn(N2O2) coordination mode were found to have in vitro insulinomimetic activity as estimated with the inhibition of free fatty acid release in isolated rat adipocytes treated with epinephrine. It was revealed that the insulinomimetic activities of zinc(II) complexes with over-all stability constants (log β) less than 10.5 are higher than those of ZnSO4 and VOSO4. The high blood glucose level of KK-Ay mice with type 2 diabetes mellitus was lowered by daily intraperitoneal injections of a zinc(II) complex, cis-[Zn(L-Thr)2(H2O)2], for 14d. The improvement of diabetes mellitus was confirmed with the oral glucose tolerance test.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0009-2363eISSN: 1347-5223DOI: 10.1248/cpb.49.652Titel-ID: cdi_proquest_miscellaneous_70884409
- Format
- –
- Schlagworte
- Adipocytes - drug effects, Adipocytes - metabolism, Adrenergic alpha-Agonists - pharmacology, amino acid, Amino Acids - chemistry, Amino Acids - pharmacology, Animals, Biological and medical sciences, Blood Glucose - metabolism, blood glucose normalizing effect, Diabetes Mellitus, Type 2 - drug therapy, Epinephrine - metabolism, Fatty Acids, Nonesterified - metabolism, General and cellular metabolism. Vitamins, Glucose Tolerance Test, Hypoglycemic Agents - chemical synthesis, Insulin - chemistry, insulinomimetic activity, Medical sciences, Mice, NIDDM, Pharmacology. Drug treatments, Zinc - chemistry, zinc(II) complex