Details

Autor(en) / Beteiligte

• Bollag, R.J
• Zhong, Q
• Ding, K.H
• Phillips, P
• Zhong, L
• Qin, F
• Cranford, J
• Mulloy, A.L
• Cameron, R
• Isales, C.M

Titel

Glucose-dependent insulinotropic peptide is an integrative hormone with osteotropic effects

Ist Teil von

• Molecular and cellular endocrinology, 2001-05, Vol.177 (1), p.35-41

Ort / Verlag

Ireland: Elsevier Ireland Ltd

Erscheinungsjahr

2001

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Glucose-dependent insulinotropic peptide (GIP) is a gut-derived hormone known to be important in modulating glucose-induced insulin secretion. In addition, GIP receptors are widely distributed and may have effects on multiple other tissues: fat cells, adrenal glands, endothelium and brain. We have demonstrated recently that GIP also has anabolic effects on bone-derived cells. We now demonstrate that GIP administration prevents the bone loss associated with ovariectomy. We propose that GIP plays a unique role in signaling the bone about nutrient availability, indicating the importance of the gut hormones in directing absorbed nutrients to the bone, and suggesting the concept of an ‘entero-osseous axis’. Thus, GIP plays an integrative role helping coordinate efficient and targeted nutrient absorption and distribution.