Details

Autor(en) / Beteiligte

• Karp, C L
• van Boxel-Dezaire, A H
• Byrnes, A A
• Nagelkerken, L

Titel

Interferon-beta in multiple sclerosis: altering the balance of interleukin-12 and interleukin-10?

Ist Teil von

• Current opinion in neurology, 2001-06, Vol.14 (3), p.361-368

Ort / Verlag

England

Erscheinungsjahr

2001

Quelle

MEDLINE

Beschreibungen/Notizen

• Interferon-beta is a remarkably pleiotropic molecule. Antiviral, pro- and antiproliferative, pro- and antiapoptotic, and complex immunoregulatory activities have all been described. The precise mechanism(s) that underlie the beneficial effects of interferon-beta in multiple sclerosis remain poorly understood; this has hindered progress in the search for more effective therapies. An increasing body of literature supports the hypothesis that interferon-beta-mediated changes in the production and activities of the immunoregulatory cytokines interleukin-12 and interleukin-10 are important to the therapeutic benefits of interferon-beta in multiple sclerosis. These data are reviewed here.