Details

Autor(en) / Beteiligte

• Rudolph, Karen M.
• Crain, Marilyn J.
• Parkinson, Alan J.
• Roberts, Marilyn C.

Titel

Characterization of a Multidrug-Resistant Clone of Invasive Streptococcus pneumoniae Serotype 6B in Alaska Using Pulsed-Field Gel Electrophoresis and PspA Serotyping

Ist Teil von

• The Journal of infectious diseases, 1999-11, Vol.180 (5), p.1577-1583

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

1999

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Antimicrobial susceptibility, pneumococcal surface protein A (PspA) serotyping, and pulsed-field gel electrophoresis (PFGE) were used to evaluate clonal relatedness among 66 invasive isolates of Streptococcus pneumoniae serotype 6B collected during 1982–1996 from patients in Alaska. Thirty-seven (56%) of the isolates had penicillin minimal inhibitory concentration values ⩾0.125 µg/mL and were resistant to at least 1 other antibiotic. Fourteen PspA serotypes were observed; PspA 16 was the most common (35%). Forty-five (68%) of the 66 isolates shared common and highly related PFGE patterns using 3 enzymes. Twenty-six (58%) of the isolates with common PFGE patterns were from Native Alaskan children ⩽2 years of age residing in 1 region of Alaska. The PFGE patterns of Alaskan serotype 6B were distinct from those of the South African 6B-8 and Spanish 6B-2 multidrug-resistant clones, suggesting that the Alaskan 6B isolates were distinct from these other pneumococcal 6B clones but genetically related to them.