Details

Autor(en) / Beteiligte

• MENDLICK, Matthew R
• NELSON, Marilu
• PICKERING, Diane
• JOHANSSON, Sonny L
• SEEMAYER, Thomas A
• NEFF, James R
• VERGARA, Gerardo
• ROSENTHAL, Howard
• BRIDGE, Julia A

Titel

Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma

Ist Teil von

• The American journal of surgical pathology, 2001-05, Vol.25 (5), p.684-687

Ort / Verlag

Hagerstown, MD: Lippincott Williams & Wilkins

Erscheinungsjahr

2001

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The cytogenetic findings for two epithelioid hemangioendotheliomas are reported. An identical chromosomal translocation involving chromosomes 1 and 3 [t(1;3)(p36.3;q25)] was detected in both cases of epithelioid hemangioendothelioma, possibly representing a characteristic rearrangement for this histopathologic entity. The presence of clonal karyotypic abnormalities supports a neoplastic origin for the epithelioid variant of hemangioendothelioma. Identification of the 1;3 translocation may be useful diagnostically. Should additional studies confirm these data, this could lead to the identification of the gene(s) central to this neoplastic process.