Biochemical and biophysical research communications, 2000-01, Vol.267 (1), p.329-333
2000
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Details
- Autor(en) / Beteiligte
- Titel
- Parthenolide Inhibits Activation of Signal Transducers and Activators of Transcription (STATs) Induced by Cytokines of the IL-6 Family
- Ist Teil von
- Biochemical and biophysical research communications, 2000-01, Vol.267 (1), p.329-333
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2000
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- Progression of inflammatory processes correlates with the release of cell-derived mediators from the local site of inflammation. These mediators, including cytokines of the IL-1 and IL-6 families, act on host cells and exert their action by activating their signal transduction pathways leading to specific target gene activation. Parthenolide, a sesquiterpene lactone found in many medical plants, is an inhibitor of IL-1-type cytokine signaling that blocks the activation of NF-κB. Here we show that parthenolide is also an effective inhibitor of IL-6-type cytokines. It inhibits IL-6-type cytokine-induced gene expression by blocking STAT3 phosphorylation on Tyr705. This prevents STAT3 dimerization necessary for its nuclear translocation and consequently STAT3-dependent gene expression. This is a new molecular mechanism of parthenolide action that additionally explains its anti-inflammatory activities.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0006-291XeISSN: 1090-2104DOI: 10.1006/bbrc.1999.1948Titel-ID: cdi_proquest_miscellaneous_70819929
- Format
- –
- Schlagworte
- Acute-Phase Proteins - metabolism, alpha 1-Antichymotrypsin - genetics, Carcinoma, Hepatocellular, Cytokines - pharmacology, DNA-Binding Proteins - metabolism, Gene Expression Regulation, Neoplastic - drug effects, Humans, IL-6, inflammation, Interleukin-1 - pharmacology, Interleukin-6 - pharmacology, Liver Neoplasms, NF-B protein, NF-kappa B - antagonists & inhibitors, NF-kappa B - metabolism, Oncostatin M, parthenolide, Peptides - pharmacology, Recombinant Fusion Proteins - biosynthesis, sesquiterpenes, Sesquiterpenes - pharmacology, Signal Transduction - drug effects, Signal Transduction - physiology, STAT3, STAT3 protein, STAT3 Transcription Factor, Trans-Activators - metabolism, Transcriptional Activation, Transfection, Tumor Cells, Cultured, tyrosine phosphorylation